HAO1

Description		hydroxyacid oxidase 1
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	(S)-2-hydroxy-acid Oxidase Activity Glycolate Oxidase Activity FMN Binding Very-long-chain-(S)-2-hydroxy-acid Oxidase Activity Long-chain-(S)-2-hydroxy-long-chain-acid Oxidase Activity Medium-chain-(S)-2-hydroxy-acid Oxidase Activity
	Biological Process	Fatty Acid Alpha-oxidation Protein Targeting To Peroxisome Response To Oxidative Stress Cellular Nitrogen Compound Metabolic Process Glycolate Catabolic Process
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		N-sulfo-flavin mononucleotide Benzoylformic Acid 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline Flavin mononucleotide Phenylpyruvic acid 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid 3-(INDOL-3-YL) LACTATE (2S)-2-HYDROXYOCTANOIC ACID Lumasiran
Diseases
GWAS		Childhood ear infection ( 27182965) Colorectal cancer ( 30529582 24836286 23263487) Colorectal cancer or advanced adenoma ( 30510241) Dentures ( 31235808) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Nose morphology ( 29921221) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Ossification of the posterior longitudinal ligament of the spine ( 25064007) QT interval ( 29213071) Smoking status (heavy vs light) ( 28520984) Systemic lupus erythematosus ( 26502338)
Interacting Genes		1 interacting genes: PEX5
Entrez ID		54363
HPRD ID		05429
Ensembl ID		ENSG00000101323
Uniprot IDs		A8K058 Q9UJM8
PDB IDs		2NZL 2RDT 2RDU 2RDW 2W0U 5QIB 5QIC 5QID 5QIE 5QIF 5QIG 5QIH 6GMB 6GMC
Enriched GO Terms of Interacting Partners?
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