PFKFB1

Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
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GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Dephosphorylation Animal Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Response To Starvation Negative Regulation Of Glycolytic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP
Pathways		PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		15 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PFKFB4 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688
Entrez ID		5207
HPRD ID		02411
Ensembl ID		ENSG00000158571
Uniprot IDs		I1Z9G4 P16118
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?
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