PDE3B

Description		phosphodiesterase 3B
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GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Lipid Catabolic Process
Pathways		PDE3B signalling PDE3B signalling G alpha (s) signalling events
Drugs		Caffeine Caffeine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ
Entrez ID		5140
HPRD ID		03626
Ensembl ID		ENSG00000152270
Uniprot IDs		A7E2E5 Q13370
PDB IDs		1SO2 1SOJ
Enriched GO Terms of Interacting Partners?
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