PDE3A

Description		phosphodiesterase 3A
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GO Annotations	Cellular Component	Cytosol Integral Component Of Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding
	Biological Process	Oocyte Maturation Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling CGMP-mediated Signaling Regulation Of Meiotic Nuclear Division Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Oocyte Development Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		G alpha (s) signalling events
Drugs		Caffeine Milrinone Anagrelide Theophylline Levosimendan Cilostazol Aminophylline Oxtriphylline Amrinone Enoximone Ibudilast Tofisopam Trapidil
Diseases
GWAS		Adiponectin levels ( 22479202 31178129) Aortic root size ( 19584346) Apolipoprotein A1 levels ( 32203549) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease x type 2 diabetes interaction ( 32541925) Degraded stimulus continuous performance test score ( 31596458) Diastolic blood pressure ( 26390057 28135244 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Gut microbiota relative abundance (Coprococcus) ( 33208821) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 28552196 31562340 18391951 29782485) Hypertension ( 30487518) Ischemic stroke ( 29531354) Lung adenocarcinoma ( 28604730) Male infertility ( 19478329) Mean arterial pressure ( 30487518) PR interval ( 32439900) Pulse pressure ( 30224653 28135244 30578418) QT interval ( 20031603) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Resting heart rate ( 29769521 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Stroke ( 29531354) Systolic blood pressure ( 28135244 28739976 27618452) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Triglyceride levels ( 32203549 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: AKT1 PRKACA YWHAQ
Entrez ID		5139
HPRD ID		00441
Ensembl ID		ENSG00000172572
Uniprot IDs		Q14432
PDB IDs		1LRC
Enriched GO Terms of Interacting Partners?
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