NPC1

Description		NPC intracellular cholesterol transporter 1
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GO Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Integral Component Of Lysosomal Membrane
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Sterol Transporter Activity Cholesterol Binding Signaling Receptor Activity
	Biological Process	Protein Glycosylation Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Cholesterol Metabolic Process Bile Acid Metabolic Process Negative Regulation Of Macroautophagy Cholesterol Transport Membrane Raft Organization Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Response To Drug Cholesterol Homeostasis Response To Cadmium Ion Viral Entry Into Host Cell Negative Regulation Of Cell Death Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane
Pathways		LDL clearance
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) White blood cell count ( 27863252)
Novel Interacting Genes		1 novel interacting genes: FURIN
Interacting Genes		5 interacting genes: BUD31 GPR35 MC4R MTDH VPS4A
Entrez ID		4864
HPRD ID		09622
Ensembl ID		ENSG00000141458
Uniprot IDs		O15118
PDB IDs		3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V
Enriched GO Terms of Interacting Partners?
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