KCND3

Description		potassium voltage-gated channel subfamily D member 3
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Postsynaptic Density Integral Component Of Membrane Sarcolemma Neuronal Cell Body Dendritic Spine Postsynaptic Membrane GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Protein Binding Ion Channel Binding Metal Ion Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Cardiac Conduction Potassium Ion Transmembrane Transport Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Nifedipine Dronedarone Vernakalant Dalfampridine Isavuconazole
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 28416822 30061737 29892015) Early cardiac repolarization ( 31600170 22683750) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Medication use (opioids) ( 31015401) Multisite chronic pain ( 31194737) P wave duration ( 24850809) P wave terminal force ( 28794112) PR interval ( 30679814 32439900) Response to radiotherapy in cancer (late toxicity) ( 24785509) TPE interval (resting) ( 32386560) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		2 interacting genes: KCNIP1 KCNIP2
Entrez ID		3752
HPRD ID		16104
Ensembl ID		ENSG00000171385
Uniprot IDs		A0A024R0C6 Q9UK17
PDB IDs		1S1G 2NZ0
Enriched GO Terms of Interacting Partners?
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