HSD17B4

Description		hydroxysteroid 17-beta dehydrogenase 4
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Enoyl-CoA Hydratase Activity Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Sertoli Cell Development
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		NADH (R)-3-hydroxydecanoyl-CoA
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Asthma ( 31959851) JT interval (sulfonylurea treatment interaction) ( 27958378) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Novel Interacting Genes		1 novel interacting genes: FER
Interacting Genes		7 interacting genes: ACTB BAK1 CASP9 CDK7 MAPK8 NDRG1 SNCA
Entrez ID		3295
HPRD ID		03514
Ensembl ID		ENSG00000133835
Uniprot IDs		A0A0S2Z4J1 B2R659 B3KSP2 P51659
PDB IDs		1IKT 1S9C 1ZBQ
Enriched GO Terms of Interacting Partners?
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