HSD11B1

Description		hydroxysteroid 11-beta dehydrogenase 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	11-beta-hydroxysteroid Dehydrogenase [NAD(P)] Activity Steroid Binding Protein Homodimerization Activity NADP Binding 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Glucocorticoid Biosynthetic Process Steroid Catabolic Process Lung Development
Pathways		Glucocorticoid biosynthesis
Drugs		NADH Carbenoxolone Nicotinamide adenine dinucleotide phosphate 2-(N-morpholino)ethanesulfonic acid Corticosterone INCB13739 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone (5S)-2-{[(1S)-1-(4-Fluorophenyl)ethyl]amino}-5-(2-hydroxy-2-propanyl)-5-methyl-1,3-thiazol-4(5H)-one (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide (5S)-2-(Cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (5R)-2-[(2-Fluorophenyl)amino]-5-isopropyl-1,3-thiazol-4(5H)-one Glycyrrhizic acid
Diseases		Cortisone reductase deficiency (CRD)
GWAS		Alopecia areata ( 25608926)
Novel Interacting Genes		1 novel interacting genes: CENPF
Interacting Genes		2 interacting genes: CD36 GKAP1
Entrez ID		3290
HPRD ID		07042
Ensembl ID		ENSG00000117594
Uniprot IDs		P28845 X5D2L1
PDB IDs		1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4C7J 4C7K 4HFR 4HX5 4IJU 4IJV 4IJW 4K1L 4P38 4YYZ 5PGU 5PGV 5PGW 5PGX 5PGY 5QII
Enriched GO Terms of Interacting Partners?
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