GSS

Description		glutathione synthetase
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Glutathione Synthase Activity Protein Binding ATP Binding Glycine Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Nervous System Development Aging Response To Xenobiotic Stimulus Response To Nutrient Levels Response To Tumor Necrosis Factor Response To Amino Acid Response To Cadmium Ion
Pathways		Glutathione synthesis and recycling Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione Glycine Cysteine gamma-Glutamylcysteine Phosphoaminophosphonic Acid-Adenylate Ester Acetylcysteine Copper
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hemostatic factors and hematological phenotypes ( 22443383) QRS complex (Cornell) ( 27659466) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: GSTZ1 TERF1
Entrez ID		2937
HPRD ID		03000
Ensembl ID		ENSG00000100983
Uniprot IDs		P48637 V9HWJ1
PDB IDs		2HGS
Enriched GO Terms of Interacting Partners?
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