PCSK9

Description		proprotein convertase subtilisin/kexin type 9
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Extrinsic Component Of External Side Of Plasma Membrane Endolysosome Membrane Perinuclear Region Of Cytoplasm PCSK9-LDLR Complex PCSK9-AnxA2 Complex
	Molecular Function	RNA Binding Serine-type Endopeptidase Activity Protein Binding Sodium Channel Inhibitor Activity Low-density Lipoprotein Particle Binding Receptor Inhibitor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Apolipoprotein Receptor Binding Protein Self-association Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Kidney Development Liver Development Negative Regulation Of Receptor Recycling Positive Regulation Of Receptor Internalization Triglyceride Metabolic Process Phospholipid Metabolic Process Apoptotic Process Lysosomal Transport Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Signaling Receptor Activity Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Autoprocessing Neurogenesis Neuron Differentiation Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Insulin Stimulus Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) VLDLR internalisation and degradation Post-translational protein phosphorylation LDL clearance
Drugs		Alirocumab Inclisiran
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 24097068 24507774 18193043 18193044 20864672 26160806 19060906 30275531 25961943 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 26690388 31087446 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Low density lipoprotein cholesterol levels ( 30718733 32154731) Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Mitochondrial DNA copy number ( 30704525) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 26690388 31087446 29403010 30275531)
Novel Interacting Genes		1 novel interacting genes: TMED5
Interacting Genes		3 interacting genes: BACE1 BIRC2 LDLR
Entrez ID		255738
HPRD ID		07080
Ensembl ID		ENSG00000169174
Uniprot IDs		Q8NBP7
PDB IDs		2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R 4NE9 4NMX 4OV6 5OCA 5VL7 5VLA 5VLH 5VLK 5VLL 5VLP 6E4Y 6E4Z 6F5G 6MV5 6OLZ 6OM0 6OM7 6U26 6U2F 6U2N 6U2P 6U36 6U38 6U3I 6U3X
Enriched GO Terms of Interacting Partners?
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