DPEP1

Description		dipeptidase 1
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GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Apical Plasma Membrane Cell Junction Anchored Component Of Membrane Microvillus Membrane Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Metalloexopeptidase Activity Zinc Ion Binding Beta-lactamase Activity GPI Anchor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metallodipeptidase Activity Modified Amino Acid Binding
	Biological Process	Proteolysis Lipid Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Apoptotic Process Inflammatory Response Antibiotic Metabolic Process Negative Regulation Of Cell Migration Neutrophil Chemotaxis Cellular Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homocysteine Metabolic Process Cellular Response To Calcium Ion Cellular Response To Nitric Oxide Cellular Lactam Catabolic Process
Pathways		Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production
Drugs		Cilastatin
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Diastolic blood pressure ( 27841878 27618447 27618448) Estimated glomerular filtration rate ( 31451708 29124443 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Hypertension ( 27618447) Hyperuricemia ( 29124443) Mean reticulocyte volume ( 32888494) Red vs. brown/black hair color ( 30531825) Serum uric acid levels ( 29124443) Systolic blood pressure ( 27841878 27618447) Urinary albumin-to-creatinine ratio ( 31511532) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: APPBP2 KIFBP
Entrez ID		1800
HPRD ID		01563
Ensembl ID		ENSG00000015413
Uniprot IDs		A0A140VJI3 P16444
PDB IDs		1ITQ 1ITU
Enriched GO Terms of Interacting Partners?
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