KLB

Description		klotho beta
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding
	Biological Process	MAPK Cascade Carbohydrate Metabolic Process Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinks per week) ( 28485404 30643258 31959922 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: FGF21 FGFR1
Entrez ID		152831
HPRD ID		14097
Ensembl ID		ENSG00000134962
Uniprot IDs		B4DYH5 Q86Z14
PDB IDs		5VAK 5VAN 5VAQ 5WI9 6NFJ
Enriched GO Terms of Interacting Partners?
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