CX3CR1

Description		C-X3-C motif chemokine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Neuronal Cell Body Membrane Neuron Projection Perinuclear Region Of Cytoplasm Dendritic Tree
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity C-C Chemokine Receptor Activity C-X3-C Chemokine Receptor Activity C-C Chemokine Binding C-X3-C Chemokine Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Response To Ischemia Chemotaxis Immune Response Cellular Defense Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Memory Response To Wounding Viral Process Calcium-mediated Signaling Central Nervous System Maturation Negative Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-1 Beta Production Social Behavior Autocrine Signaling Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Synaptic Plasticity Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Synapse Maturation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Transforming Growth Factor Beta Stimulus Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Multiple Spine Synapse Organization, Single Dendrite Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of I-kappaB Phosphorylation Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Migration Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autoimmune thyroid disease ( 32581359) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: CCDC167 CX3CL1
Entrez ID		1524
HPRD ID		03277
Ensembl ID		ENSG00000168329
Uniprot IDs		P49238
PDB IDs
Enriched GO Terms of Interacting Partners?
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