ADAMTS5

Description		ADAM metallopeptidase with thrombospondin type 1 motif 5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Extracellular Matrix Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium Tooth Eruption Negative Regulation Of Cold-induced Thermogenesis
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Batimastat (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 29343252) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681)
Interacting Genes		2 interacting genes: ACAN MMP13
Entrez ID		11096
HPRD ID		05420
Ensembl ID		ENSG00000154736
Uniprot IDs		Q9UNA0
PDB IDs		2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT
Enriched GO Terms of Interacting Partners?
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