IQGAP2

Description		IQ motif containing GTPase activating protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Positive Regulation Of GTPase Activity Thrombin-activated Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization
Pathways		RHO GTPases activate IQGAPs Neutrophil degranulation
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Novel Interacting Genes		1 novel interacting genes: ALG8
Interacting Genes		5 interacting genes: ACTR2 CALM1 CDC42 RAC1 RHOG
Entrez ID		10788
HPRD ID		09253
Ensembl ID		ENSG00000145703
Uniprot IDs		B7Z7U6 B7Z7X2 Q13576 Q59HA3
PDB IDs		3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?
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