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PLK4

Description polo like kinase 4
Image
GO Annotations Cellular Component
  • Spindle Pole
  • XY Body
  • Nucleus
  • Nucleolus
  • Cytoplasm
  • Centrosome
  • Centriole
  • Cytosol
  • Cleavage Furrow
  • Deuterosome
Molecular Function
  • Protein Serine/threonine Kinase Activity
  • Protein Binding
  • ATP Binding
  • Identical Protein Binding
Biological Process
  • G2/M Transition Of Mitotic Cell Cycle
  • Mitotic Cell Cycle
  • Protein Phosphorylation
  • Centriole Replication
  • Regulation Of G2/M Transition Of Mitotic Cell Cycle
  • Regulation Of Cytokinesis
  • Positive Regulation Of Centriole Replication
  • Trophoblast Giant Cell Differentiation
  • Ciliary Basal Body-plasma Membrane Docking
  • De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • AURKA Activation by TPX2
Drugs
  • Fostamatinib
Diseases
GWAS
Interacting Genes 22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID 10733
HPRD ID 10387
Ensembl ID ENSG00000142731
Uniprot IDs O00444
PDB IDs 2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025