NRG3

Description		neuregulin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Chemorepellent Activity
	Biological Process	Regulation Of Cell Growth Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Pattern Specification Process Chemorepulsion Involved In Interneuron Migration From The Subpallium To The Cortex Intracellular Signal Transduction Animal Organ Development Modulation Of Chemical Synaptic Transmission Mammary Placode Formation Negative Regulation Of Neuron Migration
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Basal metabolic rate ( 26865924) Bipolar disorder and eating disorder ( 26433762) Cardiac hypertrophy ( 21348951) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Fasting insulin (dietary factor interaction) ( 24204828) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Influenza A (H1N1) infection ( 26379185) Kidney disease (early and late stages) in type 1 diabetes ( 27647854) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Response to iloperidone treatment (QT prolongation) ( 18521091) Retinopathy in non-diabetics ( 23393555) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Western dietary pattern ( 28644415)
Novel Interacting Genes		1 novel interacting genes: PTPN11
Interacting Genes		1 interacting genes: ERBB4
Entrez ID		10718
HPRD ID		16115
Ensembl ID		ENSG00000185737
Uniprot IDs		B3KVG8 B9EGV5 P56975
PDB IDs
Enriched GO Terms of Interacting Partners?
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