CAMKK2

Description		calcium/calmodulin dependent protein kinase kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuron Projection
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs
Drugs		Fostamatinib
Diseases
GWAS		Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)
Interacting Genes		7 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 NEDD4 PRKACA
Entrez ID		10645
HPRD ID		06467
Ensembl ID		ENSG00000110931
Uniprot IDs		A0A024RBP6 A0A024RBP8 A0A024RBQ0 A0A024RBQ3 Q96RR4
PDB IDs		2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL 6Y8A
Enriched GO Terms of Interacting Partners?
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