SPON1

Description		spondin 1
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding LBD Domain Binding
	Biological Process	Cell Adhesion Positive Regulation Of Protein Processing Positive Regulation Of Protein Binding Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Bone mineral density (total hip) ( 29883787) Brain connectivity ( 23471985) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Inflammatory biomarkers ( 22228203) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) P wave terminal force ( 28794112) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Sense of smell ( 26632684) Tuberculosis ( 24057671)
Interacting Genes		4 interacting genes: APP CYSRT1 MDFI MEOX2
Entrez ID		10418
HPRD ID		16087
Ensembl ID		ENSG00000262655
Uniprot IDs		Q9HCB6
PDB IDs		2ZOT 2ZOU 3COO 3Q13
Enriched GO Terms of Interacting Partners?
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