CDC34 and UBE3B

Number of citations of the paper that reports this interaction (PubMedID 33298911)
3

Data Source:
BioGRID (pull down)

		CDC34	UBE3B
Description		cell division cycle 34, ubiqiutin conjugating enzyme	ubiquitin protein ligase E3B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of CAMP-mediated Signaling Response To Growth Factor Protein K48-linked Ubiquitination Positive Regulation Of Inclusion Body Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Coronary artery disease ( 32469254) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 20864672) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Mean corpuscular hemoglobin ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) PR interval ( 32439900) Total cholesterol levels ( 33339817 30275531)
Interacting Genes		57 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PRKN PTTG1 RBX1 RELA RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM21 TRIM28 TRIM29 UBA1 UBB UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1	3 interacting genes: CDC34 HRAS MYC
Entrez ID		997	89910
HPRD ID		00306	06993
Ensembl ID		ENSG00000099804	ENSG00000151148
Uniprot IDs		A0A024R1Z1 P49427	A0A024RBI2 Q7Z3V4
PDB IDs		2OB4 3RZ3 4MDK
Enriched GO Terms of Interacting Partners?
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