CDC25B and YWHAB

Number of citations of the paper that reports this interaction (PubMedID 17292828)
230

Data Source:
HPRD (in vitro, in vivo)

		CDC25B	YWHAB
Description		cell division cycle 25B	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol	Nucleus Cytoplasm Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Kinase Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle	Protein Targeting Signal Transduction Cellular Protein Localization Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Sequestering Of Protein
Pathways		Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs		L-cysteic acid	Copper Phenethyl Isothiocyanate
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Cognitive decline rate in late mild cognitive impairment ( 26252872) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) SAPHO syndrome ( 33816493)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)
Interacting Genes		28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ	143 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DCAF7 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		994	7529
HPRD ID		00307	03184
Ensembl ID		ENSG00000101224	ENSG00000166913
Uniprot IDs		B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305 Q6MZW8	P31946 V9HWD6
PDB IDs		1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9	2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP
Enriched GO Terms of Interacting Partners?
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