RHOBTB1 and ARID5B

		RHOBTB1	ARID5B
Description		Rho related BTB domain containing 1	AT-rich interaction domain 5B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Cell Cortex Endosome Membrane Cytoplasmic Vesicle Cell Projection	Nucleus Nucleoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Nitrogen Compound Metabolic Process Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor
Pathways		RHOBTB1 GTPase cycle	HDMs demethylate histones
Drugs
Diseases
GWAS		Diastolic blood pressure ( 19430483) Food allergy ( 25710614) Lean body mass ( 28552196) Metabolite levels ( 23823483) Milk allergy ( 25710614) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 28817678 22076464 25310577 23512250 33891562 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 29760442 30894546) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 32888494 27863252) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 32723749 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum metabolite levels ( 33031748) Serum total protein level ( 23022100) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 27399966 23273568 33272962 26502338) Tinnitus ( 33742053) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 32499647) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: ARID5B CUL5	9 interacting genes: ANXA7 CAMK2G CCND2 LZTS1 NRBF2 RHOBTB1 RIOX2 SLC22A1 USP54
Entrez ID		9886	84159
HPRD ID		06299	18880
Ensembl ID		ENSG00000072422	ENSG00000150347
Uniprot IDs		A0A024QZL4 O94844	Q14865
PDB IDs			1IG6 2OEH
Enriched GO Terms of Interacting Partners?
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