GAB2 and TNFRSF11A

Number of citations of the paper that reports this interaction (PubMedID 15750601)
51

Data Source:
HPRD (in vitro, in vivo)

		GAB2	TNFRSF11A
Description		GRB2 associated binding protein 2	TNF receptor superfamily member 11a
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Osteoclast Differentiation Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol-mediated Signaling	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Positive Regulation Of Bone Resorption Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Multinuclear Osteoclast Differentiation
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			ENMD-1198
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Aspartate aminotransferase levels ( 33547301) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 21102462 25231870) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604728 28604732 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100) Serum alkaline phosphatase levels ( 33547301 29403010 33339817) Vitiligo ( 27723757)
Interacting Genes		30 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TENM4 TNFRSF11A ZAP70	14 interacting genes: CBL CBLB ETFA FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		9846	8792
HPRD ID		05866	04609
Ensembl ID		ENSG00000033327	ENSG00000141655
Uniprot IDs		Q9UQC2	Q9Y6Q6
PDB IDs		2VWF 2W0Z 5EWZ 5EXA 6Y3R 6Y3S	1LB5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?