RNF40 and GRIN2A

		RNF40	GRIN2A
Description		ring finger protein 40	glutamate ionotropic receptor NMDA type subunit 2A
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Membrane Extrinsic Component Of Membrane HULC Complex Neuron Projection Axon Terminus	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cytoplasmic Vesicle Membrane Presynaptic Membrane Dendritic Spine Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Syntaxin-1 Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Protein Binding Zinc Ion Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Histone H2B Ubiquitination Response To Peptide Hormone Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Histone H2B Ubiquitination	Startle Response Response To Amphetamine Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Visual Learning Response To Xenobiotic Stimulus Response To Wounding Sensory Perception Of Pain Calcium-mediated Signaling Neurogenesis Sleep Directional Locomotion Ionotropic Glutamate Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Activation Of Cysteine-type Endopeptidase Activity Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Cellular Response To Amyloid-beta
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Felbamate Memantine Halothane Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 33263727 31043756) Bipolar I disorder ( 31043756) Chronic kidney disease ( 26420894) Clostridioides difficle infection ( 33841421) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Daytime nap ( 33568662) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Hallux valgus ( 32131869) Hepatitis B ( 22004137) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 25056061 29483656 30285260) Tenofovir clearance in HIV infection ( 26148204) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)
Interacting Genes		27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DISC1 DUSP29 EEF1D GRIN2A ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL RB1 RNF20 SFR1 TRIM51 UBE2A UBE2B UBE2D2 UBE2E1 UBE2I UBE2L6 ZCCHC12 ZNF451	41 interacting genes: ACOT8 ACTN1 AKT1 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CARHSP1 CASK CDK5 CSNK2A1 CSNK2A2 CSNK2B DLG1 DLG2 DLG3 DLG4 DLGAP1 EML1 FYN GRIN1 GRIN2B GRIN3A GRIN3B ID4 IL16 NEDD4 PATJ PCDH8 PLA2G10 PLCG1 PRKCA PRM1 PTK2B PTPN4 RGS3 RNF40 SPTAN1 SRC
Entrez ID		9810	2903
HPRD ID		07411	00698
Ensembl ID		ENSG00000103549	ENSG00000183454
Uniprot IDs		A8K6K1 O75150	A0A6Q8PGD2 Q12879 Q547U9 Q59EW6
PDB IDs			3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH
Enriched GO Terms of Interacting Partners?
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