DHX38 and AARS1

		DHX38	AARS1
Description		DEAH-box helicase 38	alanyl-tRNA synthetase 1
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity	TRNA Binding Aminoacyl-tRNA Editing Activity Ser-tRNA(Ala) Hydrolase Activity Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding Amino Acid Binding Translation Regulator Activity
	Biological Process	MRNA Splicing, Via Spliceosome	TRNA Modification TRNA Aminoacylation For Protein Translation Alanyl-tRNA Aminoacylation TRNA Processing Cerebellar Purkinje Cell Layer Development Negative Regulation Of Neuron Apoptotic Process Neuromuscular Process Controlling Balance Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Regulation Of Cytoplasmic Translational Fidelity
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Cytosolic tRNA aminoacylation
Drugs			Alanine
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 28240269 23696881) Cholesterol, total ( 25961943 20686565) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		16 interacting genes: AARS1 ACTL7B BCO1 CDC40 CMTM3 CSNK2A1 CTCF E2F4 MFAP1 NDRG4 NOL3 PPP4C SNRNP200 TNFRSF4 U2AF1 WBP4	5 interacting genes: CDC42 DHX38 EEF1B2 LINC01554 SUMO2
Entrez ID		9785	16
HPRD ID		05720	03042
Ensembl ID		ENSG00000140829	ENSG00000090861
Uniprot IDs		Q92620	P49588
PDB IDs		5YZG 6ZYM 7A5P	4XEM 4XEO 5KNN 5T5S 5T76 5V59
Enriched GO Terms of Interacting Partners?
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