CEP57 and MAGEA2B

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid, two hybrid)

		CEP57	MAGEA2B
Description		centrosomal protein 57	MAGE family member A2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Centrosome Cytosol Microtubule	Nucleus PML Body
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Microtubule Anchoring Protein Homooligomerization	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Sumoylation Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 30423114 24390342) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		48 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 DISC1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	24 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 CEP57L1 COQ4 COX7C DYNLRB1 KRT8P12 MBD3 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TRIM28 TRIM31 TUBB ZNF655
Entrez ID		9702	266740
HPRD ID		16261	14347
Ensembl ID		ENSG00000166037	ENSG00000183305
Uniprot IDs		Q86XR8	A0A024RC17 P43356
PDB IDs		4L0R
Enriched GO Terms of Interacting Partners?
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