CD63 and TIMP1

Number of citations of the paper that reports this interaction (PubMedID 16917503)
109

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo, two hybrid)

		CD63	TIMP1
Description		CD63 molecule	TIMP metallopeptidase inhibitor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Multivesicular Body Membrane Azurophil Granule Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Multivesicular Body, Internal Vesicle	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity
	Biological Process	Positive Regulation Of Receptor Internalization Cell-matrix Adhesion Protein Transport Cell Migration Cellular Protein Localization Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Activation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Aging Positive Regulation Of Cell Population Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway
Pathways		Platelet degranulation Neutrophil degranulation	Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cardiac Troponin-T levels ( 31014085) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: AP4M1 CD82 CD9 F2RL1 GLP1R HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SLC22A1 SLC22A2 SRF TIMP1 TMEM80 VKORC1	8 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5
Entrez ID		967	7076
HPRD ID		01121	02371
Ensembl ID		ENSG00000135404	ENSG00000102265
Uniprot IDs		A0A024RB05 P08962	B4DJK3 P01033 Q6FGX5
PDB IDs			1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D
Enriched GO Terms of Interacting Partners?
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