FEZ1 and NEK1

Number of citations of the paper that reports this interaction (PubMedID 14690447)
34

Data Source:
HPRD (two hybrid, in vitro)

		FEZ1	NEK1
Description		fasciculation and elongation protein zeta 1	NIMA related kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly	Protein Phosphorylation Cell Cycle Peptidyl-tyrosine Phosphorylation DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)	Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)
Interacting Genes		57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	27 interacting genes: ANXA10 ATRX CFAP410 CLCN3 CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 GTF2H4 H2BC21 HAND2 HIP1R KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD RTN4R SIRPA TAF9 TP53BP1 TSC2 YWHAH ZNF350
Entrez ID		9638	4750
HPRD ID		09212	06847
Ensembl ID		ENSG00000149557	ENSG00000137601
Uniprot IDs		Q99689	Q5JXL9 Q96PY6
PDB IDs			4APC 4B9D
Enriched GO Terms of Interacting Partners?
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