LITAF and TOM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LITAF	TOM1
Description		lipopolysaccharide induced TNF factor	target of myb1 membrane trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Cytoplasmic Side Of Early Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding WW Domain Binding	Protein Binding Clathrin Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Regulation Of Cytokine Production Regulation Of Transcription By RNA Polymerase II Aging Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of NIK/NF-kappaB Signaling	Endocytosis Signal Transduction Protein Transport Endosomal Transport
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gallstone disease ( 30504769) Heel bone mineral density ( 30598549) Hip index ( 34021172) Inflammatory bowel disease ( 28067908 23128233) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Monocyte percentage of white cells ( 32888494) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409 29874175) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Triglyceride levels ( 34074324) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		43 interacting genes: ARID5A ATXN1 BAG3 CALCOCO2 COMT CREB5 DAZAP2 EPN1 EPN2 EPN3 GGA3 HGS HIP1 HPCAL1 HPCAL4 ITCH KCNIP1 KCNIP4 N4BP1 NCALD NEDD4 OPTN PLOD2 POGZ RADIL RASSF3 REEP6 RNF208 RPS27A SMAD2 STAM2 STAT6 TAX1BP1 TNIP1 TNIP3 TOM1 UBA52 UBQLN1 UBQLN2 VENTX VSNL1 WWOX ZIC1	24 interacting genes: APP CLTC DAZAP2 DNAL4 EEA1 ILVBL LITAF LRRC20 MAP3K1 MYO6 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SSBP2 TAB1 TOLLIP UBC UBE2D1 ZFYVE16 ZNF512B
Entrez ID		9516	10043
HPRD ID		10354	05265
Ensembl ID		ENSG00000189067	ENSG00000100284
Uniprot IDs		Q99732	B3KUF5 O60784
PDB IDs			1ELK 1WRD 2N2N 2N9D 6J56
Enriched GO Terms of Interacting Partners?
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