FHL5 and IP6K3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FHL5	IP6K3
Description		four and a half LIM domains 5	inositol hexakisphosphate kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Z Disc	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding	Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Inositol Heptakisphosphate Kinase Activity Inositol Hexakisphosphate 6-kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Inositol Diphosphate Tetrakisphosphate Kinase Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Protein Phosphorylation Inositol Phosphate Biosynthetic Process Locomotion Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process
Pathways			Synthesis of pyrophosphates in the cytosol
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 23850713) HDL cholesterol levels ( 32203549) Height ( 28552196) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and waist-to-hip-ratio (pleiotropy) ( 26920376) Phosphorus levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Regular attendance at a gym or sports club ( 29970889)
Interacting Genes		90 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FAM214B FAM71C FARS2 FEZF1 FHL2 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 PPP1R32 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF131 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1	14 interacting genes: FHL5 KRTAP10-8 LNX1 MED4 MEOX2 NIF3L1 NOTO POLR2E TRAF2 TRAF3 TRIM27 TRIP6 ZNF655 ZRANB1
Entrez ID		9457	117283
HPRD ID		05497	07381
Ensembl ID		ENSG00000112214	ENSG00000161896
Uniprot IDs		Q5TD97	A8K1M0 Q5TAQ4 Q96PC2
PDB IDs		1X68
Enriched GO Terms of Interacting Partners?
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