EIF2AK3 and NFE2L2

Number of citations of the paper that reports this interaction (PubMedID 14517290)
409

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		EIF2AK3	NFE2L2
Description		eukaryotic translation initiation factor 2 alpha kinase 3	nuclear factor, erythroid 2 like 2
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Endoplasmic Reticulum Organization Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Calcium-mediated Signaling Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Cold Positive Regulation Of Protein Localization To Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Manganese-induced Endoplasmic Reticulum Stress	Regulation Of Transcription By RNA Polymerase II Inflammatory Response Aging Response To Lithium Ion Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PERK regulates gene expression ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	ROS sensing by NFE2L2 ROS sensing by NFE2L2 Regulation of HMOX1 expression and activity Heme signaling
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Progressive supranuclear palsy ( 21685912)	Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2	80 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TNNT1 TRIM24 UBE2E2 WAC ZBTB24 ZNF396
Entrez ID		9451	4780
HPRD ID		04942	02732
Ensembl ID		ENSG00000172071	ENSG00000116044
Uniprot IDs		B3KY45 Q68DI6 Q9NZJ5	Q16236
PDB IDs		4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7	2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V
Enriched GO Terms of Interacting Partners?
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