MAP4K4 and TBPL2

Number of citations of the paper that reports this interaction (PubMedID 15234975)
36

Data Source:
BioGRID (two hybrid)

		MAP4K4	TBPL2
Description		mitogen-activated protein kinase kinase kinase kinase 4	TATA-box binding protein like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion	Nucleus Cytoplasm
	Molecular Function	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity	DNA Binding RNA Polymerase II General Transcription Initiation Factor Activity General Transcription Initiation Factor Activity
	Biological Process	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Neuron Projection Regeneration Positive Regulation Of Focal Adhesion Disassembly	DNA-templated Transcription, Initiation Transcription By RNA Polymerase II
Pathways		Oxidative Stress Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)	Blood protein levels ( 28240269) Early spontaneous preterm birth ( 31194736) Pediatric bone mineral content (femoral neck) ( 28181694) Pediatric bone mineral density (femoral neck) ( 28181694) Pediatric bone mineral density (hip) ( 28181694) Platelet count ( 32888494 27863252) Testicular germ cell tumor ( 28604728)
Interacting Genes		18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	4 interacting genes: DNAJB4 DNAJB5 KPNA2 MAP4K4
Entrez ID		9448	387332
HPRD ID		05235	10607
Ensembl ID		ENSG00000071054	ENSG00000182521
Uniprot IDs		B7Z3V5 O95819 V9HWH3	Q6SJ96
PDB IDs		4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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