MED23 and ETS1

Number of citations of the paper that reports this interaction (PubMedID 15572696)
93

Data Source:
BioGRID (unspecified method)

		MED23	ETS1
Description		mediator complex subunit 23	ETS proto-oncogene 1, transcription factor
Image
GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Coactivator Activity Histone Acetyltransferase Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Immune Response Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Hypothalamus Development Pituitary Gland Development Cell Differentiation PML Body Organization Response To Estradiol Response To Laminar Fluid Shear Stress Positive Regulation Of Blood Vessel Endothelial Cell Migration Estrous Cycle Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement Angiogenesis Involved In Wound Healing Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Oncogene Induced Senescence
Drugs
Diseases
GWAS		L-arginine levels ( 25245031) Type 2 diabetes ( 30054458)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 22057235 20190752 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 30054594) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 22446963 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 20169177 28714469 19838193) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30054458 30297969 30718926) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 27863252)
Interacting Genes		16 interacting genes: CEBPB CLCN3 CTDP1 ELF3 ESR1 ESR2 ETS1 FOXJ3 MED13 MED9 NCOA6 PUM2 RELA SREBF1 VDR WDTC1	58 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B CBL CFP COP1 CREBBP CYBC1 DAXX DNMT3L DPAGT1 EIF5B EP300 EPHA4 ETS2 FOS GATA3 HMBS HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 QPRT RBBP6 RPL13A RUNX1T1 RUNX2 SLC37A4 SMAD3 SP1 SP100 SPI1 SPIRE1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		9439	2113
HPRD ID		05436	01260
Ensembl ID		ENSG00000112282	ENSG00000134954
Uniprot IDs		Q05DL5 Q9ULK4	A8K725 B4DW78 P14921
PDB IDs		6H02	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?
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