FAM189A2 and UBXN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		FAM189A2	UBXN1
Description		family with sequence similarity 189 member A2	UBX domain protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Dendrite VCP-NPL4-UFD1 AAA ATPase Complex Neuronal Cell Body
	Molecular Function	Molecular_function Protein Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding
	Biological Process	Biological_process	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-specific Protease Activity
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Coronary artery disease in type 1 diabetes ( 29695241)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: BAG3 CALCOCO2 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2	20 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HMGB1 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2
Entrez ID		9413	51035
HPRD ID		16255	11266
Ensembl ID		ENSG00000135063	ENSG00000162191
Uniprot IDs		A0A0A0MR12 A0A6F8PH59 Q15884 Q8WU02	A0A024R539 A0A024R598 A0A087WTZ5 Q04323
PDB IDs
Enriched GO Terms of Interacting Partners?
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