FBXO44 and NPHP4

		FBXO44	NPHP4
Description		F-box protein 44	nephrocystin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Structural Molecule Activity Protein Binding
	Biological Process	Glycoprotein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Neurological blood protein biomarker levels ( 31320639)	Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)
Interacting Genes		13 interacting genes: BLOC1S1 BORCS6 BRCA1 C11orf45 HSF2BP ISY1-RAB43 MEOX2 NPHP4 PRDM5 SERTAD3 SKP1 SPG21 UBC	8 interacting genes: C1orf127 EDIL3 FBXO44 NPHP1 RBP7 RPGRIP1 SCRG1 TMEM201
Entrez ID		93611	261734
HPRD ID		16445	06238
Ensembl ID		ENSG00000132879	ENSG00000131697
Uniprot IDs		A0A024R4F9 A0A024R4J6 B7Z1P2 Q9H4M3	B3KW36 O75161
PDB IDs		3WSO 5B4N
Enriched GO Terms of Interacting Partners?
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