ZNHIT3 and XRCC3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		ZNHIT3	XRCC3
Description		zinc finger HIT-type containing 3	X-ray repair cross complementing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Pre-snoRNP Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding Thyroid Hormone Receptor Binding	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Box C/D SnoRNP Assembly Regulation Of Transcription, DNA-templated SnoRNA Localization	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Body mass index ( 26426971) Multiple sclerosis ( 31604244) Red cell distribution width ( 32888494 27863252 28957414)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: CSNK2A2 ESR2 FCMR HNF4A MBNL1 MEIS2 NUFIP1 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		9326	7517
HPRD ID		05139	07201
Ensembl ID		ENSG00000273611	ENSG00000126215
Uniprot IDs		A0A024R0X8 Q15649	O43542 Q53XC8
PDB IDs		2YQQ 5L85
Enriched GO Terms of Interacting Partners?
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