MED14 and SREBF1

Number of citations of the paper that reports this interaction (PubMedID 16799563)
177

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)

		MED14	SREBF1
Description		mediator complex subunit 14	sterol regulatory element binding transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Stem Cell Population Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Lipid Localization Regulation Of Lipid Storage Regulation Of Fatty Acid Metabolic Process Lung Development Intracellular Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone SREBP Signaling Pathway Response To Glucagon MRNA Transcription By RNA Polymerase II Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases
GWAS		Migraine ( 27322543)	Coffee consumption ( 31046077) Eosinophil counts ( 32888494) Hip index ( 34021172) Lymphocyte counts ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ACTN1 ACTN2 AR CTDP1 DCTN1 ESR1 ESR2 FBXL17 HNF4A MED1 MED29 MED9 NECAB2 NR3C1 PARP1 PPARGC1A SREBF1 STAT2 UACA VDR	41 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP EP300 ESR1 ESR2 FBXW7 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MAPK7 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		9282	6720
HPRD ID		02172	01701
Ensembl ID		ENSG00000180182	ENSG00000072310
Uniprot IDs		O60244	A8MTU8 B3KR77 P36956
PDB IDs			1AM9
Enriched GO Terms of Interacting Partners?
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