MFHAS1 and CLK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
16

Data Source:
BioGRID (pull down)

		MFHAS1	CLK1
Description		multifunctional ROCO family signaling regulator 1	CDC like kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Cytoskeleton	Nucleus Cytoplasm
	Molecular Function	Protein Binding GTP Binding Ubiquitin Protein Ligase Binding Protein Phosphatase 2A Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Inflammatory Response Erythrocyte Differentiation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Dephosphorylation Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade	Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways
Drugs			Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Adventurousness ( 30643258) Age at first sexual intercourse ( 27089180) Aspartate aminotransferase levels ( 33547301) Bipolar disorder (early vs late onset) ( 34016946) Body shape index ( 34021172) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cooked vegetable consumption ( 32066663) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 29187730) Neuroticism ( 29255261) Processed meat consumption ( 32066663) Refractive error ( 32231278) Skin aging (microtopography measurement) ( 28502801) Systemic lupus erythematosus ( 28714469) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		88 interacting genes: ABLIM1 AGFG1 AHCYL1 AHDC1 ANKRD13A ANKRD13D ANKS4B APEX2 AURKB BAG2 CABP4 CALM1 CALML3 CALU CAPRIN1 CBLB CCDC149 CCDC43 CDC42EP3 CEBPZ CEP85 CETN3 CHGB CLK1 COPB2 CRTC2 CUEDC1 CYREN DDI1 DRC3 E2F4 EGLN2 ESRRG ETV5 FGF16 FGFR1 FOXN3 GAK GAS2L3 GPBP1L1 GSDMD GTSF1 HIC2 IFTAP KLHDC4 LIMA1 LIMK1 MAP3K4 MRGBP NEK1 NEK11 PDCL PGRMC2 PJA2 PMM1 POLA2 POLI PPARG PRKAG2 PSME3IP1 RASL11B RCN2 RHBDD1 ROR1 RPAP3 RTKN SELENOS SH2D2A SLC4A1AP SMTNL2 SNAI1 STK25 STN1 STUB1 SUPT4H1 TADA3 TAS2R60 TBC1D22B TOX2 TRAPPC2 TRIM22 TTC27 UBL7 VGLL4 VN1R1 WWTR1 ZFAND5 ZMYM5	167 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 BCS1L C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTLA4 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ERFE FAM189A1 FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MFSD10 MICU3 MKRN2 MTBP MTCL1 MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRPF38A PRPF4 PRPF4B PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF3 SRSF5 SRSF6 SRSF7 SSBP3 STIP1 STK31 SVOP TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148
Entrez ID		9258	1195
HPRD ID		12010	09058
Ensembl ID		ENSG00000147324	ENSG00000013441
Uniprot IDs		Q9Y4C4	P49759
PDB IDs			1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3
Enriched GO Terms of Interacting Partners?
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