MAGI1 and ATF6

Number of citations of the paper that reports this interaction (PubMedID 30944250)
11

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MAGI1	ATF6
Description		membrane associated guanylate kinase, WW and PDZ domain containing 1	activating transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Junction Cell Projection Cell Periphery	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Alpha-actinin Binding Molecular Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Protein-containing Complex Assembly	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes
Drugs			Pseudoephedrine
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 32853455) Cobalt levels ( 26025379) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Cortical surface area (MOSTest) ( 32665545) Crohn's disease-related phenotypes ( 25557950) Declining hemoglobin trajectory in blood donors ( 33491795) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Knee osteoarthritis ( 28916551) Neurociticism ( 29500382) Neuroticism ( 25993607) Nicotine dependence symptom count ( 25555482) Ocular sarcoidosis ( 32141793) Ocular sarcoidosis in sarcoidosis ( 32141793) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 23534349) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tinnitus ( 33742053)	Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)
Interacting Genes		27 interacting genes: ACTN4 ADGRB1 AMOT ASIC3 ATF6 ATN1 CLCN5 CRHR1 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 PRRG4 RAC1 RASA1 RASL11B RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	16 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		9223	22926
HPRD ID		04020	16118
Ensembl ID		ENSG00000151276	ENSG00000118217
Uniprot IDs		Q96QZ7	A8K383 P18850
PDB IDs		1WBP 2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU 5N7D 5N7F 5N7G 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
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