MTA2 and UBE3C

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MTA2	UBE3C
Description		metastasis associated 1 family member 2	ubiquitin protein ligase E3C
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Proteasome Complex Nucleus
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Chromatin Remodeling Regulation Of Fibroblast Migration Histone Deacetylation Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)
Interacting Genes		23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	12 interacting genes: APP CAND2 CCNB1 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		9219	9690
HPRD ID		07233	15604
Ensembl ID		ENSG00000149480	ENSG00000009335
Uniprot IDs		A0A024R534 O94776	Q15386
PDB IDs			6K2C
Enriched GO Terms of Interacting Partners?
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