RNF185 and CGAS

Number of citations of the paper that reports this interaction (PubMedID 28273161)
38

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RNF185	CGAS
Description		ring finger protein 185	cyclic GMP-AMP synthase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment	Nucleus Cytosol Plasma Membrane Site Of Double-strand Break
	Molecular Function	Protein Binding Ubiquitin Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Metal Ion Binding 2',3'-cyclic GMP-AMP Synthase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Ubiquitin-dependent ERAD Pathway ERAD Pathway Protein Autoubiquitination Transmembrane Transport ER-associated Misfolded Protein Catabolic Process Positive Regulation Of ERAD Pathway Endoplasmic Reticulum Mannose Trimming	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Immunoglobulin Production DNA Repair Cellular Response To DNA Damage Stimulus Determination Of Adult Lifespan Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Type I Interferon Production Paracrine Signaling Positive Regulation Of CAMP-mediated Signaling Innate Immune Response Regulation Of T Cell Activation Defense Response To Virus Cellular Response To Exogenous DsRNA Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cellular Senescence
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)	STING mediated induction of host immune responses
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: APP CGAS CMTM5 CYB561A3 DVL2 FAM241B MALL MS4A13 MTNR1B MYADML2 NIPAL4 TMEM147 TMEM19 TMEM86A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2V1 UBE2W USP21 YIPF2 YIPF4 YIPF6	1 interacting genes: RNF185
Entrez ID		91445	115004
HPRD ID		08790	12857
Ensembl ID		ENSG00000138942	ENSG00000164430
Uniprot IDs		A0A024R1F5 A0A024R1H4 Q96GF1	Q8N884
PDB IDs			4KM5 4LEV 4LEW 4MKP 4O67 4O68 4O69 5V8O 5VDO 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV 5VDW 6CT9 6CTA 6EDB 6EDC 6LRC 6LRE 6LRI 6LRJ 6LRK 6LRL 6MJU 6MJW 6MJX 6NAO 6NFG 6NFO 6O47 6Y5D 6Y5E 7C0M 7CCQ 7CCR
Enriched GO Terms of Interacting Partners?
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