USP2 and IKBKG

Number of citations of the paper that reports this interaction (PubMedID 14695475)
174

Data Source:
BioGRID (enzymatic study)

		USP2	IKBKG
Description		ubiquitin specific peptidase 2	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator	Apoptotic Process Inflammatory Response Immune Response Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Positive Regulation Of Macroautophagy Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Establishment Of Vesicle Localization Protein-containing Complex Assembly Negative Regulation Of Neuron Death
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs			AGRO100 Tarenflurbil
Diseases
GWAS		Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486)	Hemoglobin levels ( 26366553)
Interacting Genes		165 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP ASPG ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BHLHB9 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CCND1 CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DDI1 DEPDC5 DISC1 DTX3 DUSP21 DYDC1 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GRB7 GRIPAP1 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF166 RUNDC3A S100A10 SH2B2 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1	245 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BIRC3 BRME1 C19orf12 CALB1 CALCOCO2 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IFIT5 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAPRE1 MARCHF2 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKDC PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RELA RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF34 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP10 USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3
Entrez ID		9099	8517
HPRD ID		05287	02217
Ensembl ID		ENSG00000036672	ENSG00000269335
Uniprot IDs		O75604	A0A087X1B1 Q9Y6K9
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4
Enriched GO Terms of Interacting Partners?
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