ASH2L and ATP1A3

		ASH2L	ATP1A3
Description		ASH2 like, histone lysine methyltransferase complex subunit	ATPase Na+/K+ transporting subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Integral Component Of Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding Chaperone Binding Ion Antiporter Activity Involved In Regulation Of Presynaptic Membrane Potential Steroid Hormone Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Histone H3-K4 Methylation	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Ouabain
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)	Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)
Interacting Genes		37 interacting genes: ACTC1 ACTN2 ANKRD1 ATP1A3 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 FURIN H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WWP1 ZSCAN1	11 interacting genes: ABCA4 ASH2L ATRX ATXN1 CASP8 DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229
Entrez ID		9070	478
HPRD ID		05309	01666
Ensembl ID		ENSG00000129691	ENSG00000105409
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	P13637 Q53ES0
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE
Enriched GO Terms of Interacting Partners?
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