LRSAM1 and MYL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		LRSAM1	MYL2
Description		leucine rich repeat and sterile alpha motif containing 1	myosin light chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding
	Biological Process	Protein Polyubiquitination Autophagy Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Regulation Of The Force Of Heart Contraction Regulation Of Striated Muscle Contraction Heart Development Negative Regulation Of Cell Growth Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Striated Muscle Contraction
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Serum uric acid levels ( 32514006) Urate levels ( 31578528) White blood cell count ( 29403010)
Interacting Genes		45 interacting genes: ATXN1 ATXN7 C5 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4	12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
Entrez ID		90678	4633
HPRD ID		14325	01181
Ensembl ID		ENSG00000148356	ENSG00000111245
Uniprot IDs		A0A024R870 Q6UWE0	P10916 Q6IB42
PDB IDs			5TBY
Enriched GO Terms of Interacting Partners?
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