MCFD2 and SLC35A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MCFD2	SLC35A1
Description		multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	solute carrier family 35 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Golgi Apparatus Integral Component Of Plasma Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane
	Molecular Function	Calcium Ion Binding Protein Binding	CMP-N-acetylneuraminate Transmembrane Transporter Activity UDP-galactose Transmembrane Transporter Activity Protein Binding Antiporter Activity
	Biological Process	Protein Transport Vesicle-mediated Transport	Carbohydrate Metabolic Process Cellular Protein Modification Process Carbohydrate Transport CMP-N-acetylneuraminate Transmembrane Transport UDP-galactose Transmembrane Transport
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification	Sialic acid metabolism Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Transport of nucleotide sugars
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)	Bone mineral density (hip) ( 30172743) Obesity-related traits ( 23251661)
Interacting Genes		11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1	36 interacting genes: AQP6 ARL13B ASGR2 ASZ1 BCL2L13 CD53 CERS4 CPLX4 EBAG9 ERGIC3 F11R F2RL1 FAM209A FNDC9 FXYD3 GPX8 KIR3DL3 LHFPL5 LMNA MCFD2 MGST3 MRPS18B PIK3IP1 PLPP4 PSCA RELL2 SAR1A SDC3 SLC1A1 SLC34A2 SSMEM1 SYT2 TCTA TMEM139 TMPRSS2 TMX2
Entrez ID		90411	10559
HPRD ID		09693	09290
Ensembl ID		ENSG00000180398	ENSG00000164414
Uniprot IDs		B4DF17 Q8NI22	P78382
PDB IDs		2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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