CCNT1 and HTATSF1

Number of citations of the paper that reports this interaction (PubMedID 11780068)
142

Data Source:
BioGRID (pull down)

		CCNT1	HTATSF1
Description		cyclin T1	HIV-1 Tat specific factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex	Nucleus Nucleoplasm U2-type Spliceosomal Complex U2 SnRNP
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding	RNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Division Negative Regulation Of MRNA Polyadenylation	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Viral Genome Replication Regulation Of DNA-templated Transcription, Elongation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		26 interacting genes: AFF4 AHR BRD4 CDK9 CEBPB ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2 SUPT5H	20 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 POLR2A SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H THAP1 WBP4 ZNF512B
Entrez ID		904	27336
HPRD ID		03938	02282
Ensembl ID		ENSG00000129315	ENSG00000102241
Uniprot IDs		A8K4M5 O60563	O43719
PDB IDs		2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6Z45	2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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