RNF8 and TMEM79

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid, two hybrid)

		RNF8	TMEM79
Description		ring finger protein 8	transmembrane protein 79
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break	Lysosomal Membrane Integral Component Of Membrane Trans-Golgi Network Membrane
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Epithelial Cell Maturation Hair Follicle Morphogenesis Cuticle Development Regulated Exocytosis Positive Regulation Of Epidermis Development Establishment Of Skin Barrier Cornification
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)	Glycated hemoglobin levels ( 24647736 28898252 29170429) Mean corpuscular hemoglobin concentration ( 20139978)
Interacting Genes		77 interacting genes: AMOTL2 BLM C2CD6 CALCOCO1 CCDC14 CCDC50 CCDC85B CEP44 CEP85 CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A KIF24 KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCNA PCYT1A PGRMC2 PICK1 PNMA2 POLD4 PSMB1 RBFOX2 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4 ZBTB10 ZNF346 ZNF496	36 interacting genes: ABO AMIGO1 ANKRD46 APOD ARL13B BRICD5 CLEC7A COQ9 CPLX4 CYB5R3 FAM209A FNDC9 GIMAP1 GPRC5D LDLRAD1 LPAR3 PELI2 PLN PLP2 PVR RNF8 RPRM SEC22A SERP1 SFTPC SLN TEX264 TMEM100 TMEM14C TMEM254 TMEM97 TMPRSS2 TMPRSS4 TNMD TRAM1L1 ZCCHC12
Entrez ID		9025	84283
HPRD ID		11521	17481
Ensembl ID		ENSG00000112130	ENSG00000163472
Uniprot IDs		O76064	Q9BSE2
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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