LACRT and VTN

Number of citations of the paper that reports this interaction (PubMedID 11419941)
44

Data Source:
HPRD (in vitro)

		LACRT	VTN
Description		lacritin	vitronectin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Extracellular Region Extracellular Space Endoplasmic Reticulum Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Fibronectin Binding Protein Binding Collagen Binding Growth Factor Activity Laminin-1 Binding Protein N-terminus Binding	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Polysaccharide Binding
	Biological Process	Protein Acetylation Positive Regulation Of Cell Population Proliferation Epithelial Structure Maintenance Positive Regulation Of Macroautophagy Calcium-mediated Signaling Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Calcineurin-NFAT Signaling Cascade Protein Localization To Golgi Apparatus Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Tear Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade
Drugs			Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)
Interacting Genes		6 interacting genes: APP FN1 NID1 SDC1 TGM2 VTN	47 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		90070	7448
HPRD ID		06302	01902
Ensembl ID		ENSG00000135413	ENSG00000109072
Uniprot IDs		Q9GZZ8	D9ZGG2 P04004
PDB IDs			1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E
Enriched GO Terms of Interacting Partners?
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