RPS6KA4 and ATF1

Number of citations of the paper that reports this interaction (PubMedID 11909979)
175

Data Source:
HPRD (in vitro)

		RPS6KA4	ATF1
Description		ribosomal protein S6 kinase A4	activating transcription factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Cellular Protein-containing Complex Assembly Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recycling pathway of L1	CREB phosphorylation NGF-stimulated transcription NGF-stimulated transcription
Drugs		Flavin mononucleotide	Pseudoephedrine
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Mean arterial pressure ( 27618448) Multiple sclerosis ( 31604244) Spleen volume ( 34128465) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 30578418)
Interacting Genes		10 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4 PDE2A	23 interacting genes: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B DNMT3L EDF1 GABPA GABPB1 HNF1B JUN MAPKAPK2 MAPKAPK3 PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		8986	466
HPRD ID		04677	00440
Ensembl ID		ENSG00000162302	ENSG00000123268
Uniprot IDs		A0PJF8 B4DPV1 E9PJN1 O75676	P18846
PDB IDs
Enriched GO Terms of Interacting Partners?
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