EIF2B5 and EIF2B2

Number of citations of the paper that reports this interaction (PubMedID 27173435)
78

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EIF2B5	EIF2B2
Description		eukaryotic translation initiation factor 2B subunit epsilon	eukaryotic translation initiation factor 2B subunit beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Aging Response To Heat Response To Glucose Response To Lithium Ion Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP	Recycling of eIF2:GDP
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494 27863252) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Coronary artery disease ( 33020668) Gastroesophageal reflux disease ( 34187846) Mood instability ( 29187730) Serum alkaline phosphatase levels ( 33547301) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		12 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B STX11	14 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 NPC2 PCGF6 TBCE TET2
Entrez ID		8893	8892
HPRD ID		04898	05923
Ensembl ID		ENSG00000145191	ENSG00000119718
Uniprot IDs		Q13144	P49770 Q53XC2
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46
Enriched GO Terms of Interacting Partners?
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